YOD1, Protein (O572-30H)
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Description : Recombinant full-length human YOD1 was expressed in E. coli cells using an N-terminal his tag.
Species : Human
Tag : His tag
Expression System : E. coli cells
Sequence : Full length
Genbank Number : NM_018566
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : 40 kDa
Gene Aliases : DUBA8; OTUD2; PRO0907
Scientific Background : YOD1 belongs to the ovarian tumor domain (OUT) containing subfamily of deubiquitinating enzymes (DUBs), which are cysteine proteases specifically removing ubiquitin from ubiquitin-conjugated protein substrates (1). YOD1 participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins via deubiquitination of 'Lys-11', 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains (2). YOD1 positively regulates the stability of ITCH resulting in the activation of YAP in liver cancer study (3).
References :
1. Sowa ME, et al. Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
2. Flierman D, et al. Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
3. Kim Y, et al. Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer. BMB Rep. 2017 Jun;50(6):281-282.
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Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder