WHSC1 (NSD2), Active(N377-381G)
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Description :Recombinant human WHSC1 (911-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :911-end
Genbank Number :NM_133330
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :80 kDa
Gene Aliases :MMSET; WHSC1; REIIBP; TRX5; WHS
Scientific Background :Histone-lysine N-methyltransferase NSD2 or Multiple myeloma SET domain-containing protein (MMSET) is a histone methyltransferase (HMT) with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Overexpressed in t(4;14)+ multiple myeloma (MM) patients, leading to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), accompanied by changes in proliferation, gene expression and chromatin accessibility.
References :
1. Shah MY, et al: MMSET/WHSC1enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.116.
2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816(2):158-63.
Product Sheets (By Lot #) :
Research Areas :Cancer, NfkB Pathway