USP16, Active (U516-381G)
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Description : Recombinant human USP16 (187-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 187-end
Genbank Number : NM_006447
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 110 kDa
Gene Aliases : UBP-M
Scientific Background : USP16 (ubiquitin carboxyl-terminal hydrolase 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and is involved in transcriptional regulation that controls cell differentiation, cell cycle and apoptosis through modulations with p16 Ink4a and p19 Arf. Downregulation of USP16 by truncated HBx may contribute to the growth of hepatocellular carcinoma cells (1). USP16 may also play a crucial role in provoking the self-renewal and/or senescence pathways in Down syndrome through the removal of ubiquitin from H2AK119, a critical mark for the maintenance of several somatic tissues (2).
References :
1. Qian, Y. et al: USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells. Scientific Reports 6, 33039, 2016.
2. Adorno, M. et al: Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature vol. 501(7467): 380-4, 2013.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder