USP15, Active (U515-380G)
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Description : Recombinant full-length human USP15 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : NM_001252078
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 130 kDa
Gene Aliases : KIAA0529, UNPH-2
Scientific Background : USP15 (ubiquitin carboxyl-terminal hydrolase 15) is a member of the ubiquitin specific protease (USP) family of cysteine protease deubiquitination enzymes and regulates TGFB receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. The enzyme interacts with OP9 signalosome and is a key regulator of TGFB receptor signaling through deubiquitination of receptor-activated SMAD transcription factors (1). USP15 also plays a role in the regulation and stabilization of Human Papillomavirus (HPV) type 16 E6 protein, suggesting that E6 may be a target for USP15 DUB activity (2).
References :
1. Inui, M. et al: USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 13(11):1368-75, 2011.
2. Vos, Robin M et al: The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. Journal of virology 83(17): 8885-92, 2009.
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Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder