USP2, Active (U502-381H)
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Description : Recombinant human USP2 (259-end), was expressed in E. coli cells using an N-terminal His tag.
Species : Human
Tag : His tag
Expression System : E.coli
Sequence : 259-end
Genbank Number : NM_004205
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 40 kDa
Gene Aliases : UBP41
Scientific Background : USP2 (Ubiquitin carboxyl-terminal hydrolase 2) is a member of the peptidase C19 superfamily and is a ubiquitin-specific protease that is essential for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. The enzyme deubiquitinates polyubiquitinated target proteins like fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. USP2 plays a role in G1/S cell-cycle progression in normal and cancer cells as it is a specific deubiquitinase for cyclin D1 (1). It is also involved in the regulation of the p53 pathway by targeting Mdm2, which is critical for maintaining genome integrity (2).
References :
1. Shan, J. et al: Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36:469-476, 2009.
2. Stevenson, L. F. et al: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO journal 26(4): 976-986, 2007.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder