TNFAIP3 (A20p37), Active (T563-381H)
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Description : Recombinant human TNFAIP3 (440-790 a.a.), or A20p37, was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species : Human
Tag : His tag
Expression System : E.coli
Sequence : 440-790 a.a.
Genbank Number : NM_006290
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 41 kDa
Gene Aliases : AISBL, A20, OTUD7C
Scientific Background : TNFAIP3 (Tumor necrosis factor alpha-induced protein 3) is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. The enzyme plays a role in immune and inflammatory responses of cytokines such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through inhibiting NFkB activity (1). TNFAIP3 has been found to be associated with rheumatoid arthritis (2).
References :
1. Heyninck, K et al: The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. Journal of cell biology vol. 145,7: 1471-82, 1999.
2. Stahl, E. A. et al: Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature genetics 42,6: 508-14, 2010
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Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder