SENP2, Active (S532-381H)
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Description : Recombinant SENP2 (360-end) was expressed in E. coli cells using an N-terminal His tag.
Species : Human
Tag : His tag
Expression System : E.coli
Sequence : 360-end
Genbank Number : NM_021627
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 28 kDa
Gene Aliases : KIAA1331, SMT3IP2, AXAM2
Scientific Background : Sentrin-specific protease 2 (SENP2) is a protease that catalyzes the hydrolysis of an alpha-linked peptide bond of the small ubiquitin-like modifier (SUMO) propeptides leading to the mature form of the proteins and the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted protein. SENP2 plays a role in the formation of adipocytes by desumolyating and promoting CEPBP stabilization (1). SENP2 also binds to Nup153, a nucleoporin that is confined to the nucleoplasmic face of the pore and localization of SENP2 to the pore may spatially restrict the activity of this enzyme (2).
References :
1. WChung, S.S. et al: Control of adipogenesis by the SUMO-specific protease SENP2. Mol. Cell. Biol. 30:2135-2146, 2010.
2. Hang, J. & Dasso, M: Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 277 (22): 19961–6, 2002.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder