SENP1, Active (S531-381H)
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Description : Recombinant human SENP1 (409-end) was expressed in E. coli cells using an N-terminal His tag.
Species : Human
Tag : His tag
Expression System : E.coli
Sequence : 409-end
Genbank Number : NM_001267594
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 27 kDa
Gene Aliases : SuPr-2
Scientific Background : SENP1 (SUMO-specific protease 1) is a protease from the de-SUMOylation protease superfamily and catalyzes the maturation of SUMO protein (small ubiquitin-related modifier). It plays a role in the regulation of androgen receptor-dependent transcription and hypoxia signaling (1). Overexpression of SENP1 was found in precancerous prostate intraepithelial neoplasia lesions and prostate cancer tissue samples, indicating the enzyme may promote prostate cancer metastasis and progression (2).
References :
1. Wenrong, X. et al: Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-κB/Akt pathways. Elsevier BV 595(2): 175-179, 2016
2. Wang, Q. et al: SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene 32(19):2493-8, 2013.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder