MINDY4, Active (M534-10G)
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Description: Recombinant full-length human MINDY4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species: Human
Tag: GST tag
Expression System: Sf9 insect cells
Sequence: Full length
Genbank Number: NM_032222
Purity: Sample Purity Data. For specific information on a given lot, see the related technical datasheet. 
Activity: Sample Purity Data. For specific information on a given lot, see the related technical datasheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : 120 kDa
Gene Aliases : FAM188B, C7orf67
Scientific Background : MINDY 4 is a member of motif interacting with Ub-containing novel DUB family. It is found in all eukaryotes and selectively cleaves K48-linked polyUb, a signal that targets protein degradations (1). It has been associated with teratospermina and solid tumors including colon cancer (2,3). The expression and function of MINDY4 has yet to be characterized, however it has been shown to play a role in sustaining cell survival in vitro and regulating growth in vivo. (3)
References :
1. Abdul Rehman SA, et al: (2016) MINDY-1 is a Member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. Mol Cell. 63(1):146‐155.
2. GEO Profiles: GDS2697 record.
3. Choi ES, et al: (2018) FAM188B enhances cell survival via interaction with USP7. Cell Death Dis. 9(6):633.
Research Areas : Cancer