MINDY1, Protein (M531-30G)
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Description : Recombinant full-length human MINDY1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full Length
Genbank Number : NM_018379
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : 95 kDa
Gene Aliases : FAM63A, MINDY lysine 48 deubiquitinase 1, MINDY-1
Scientific Background : MINDY1, as a member of the motif interacting with Ub-containing novel DUB family, is widely expressed in human tissues and during development (1). It cleaves long polyUb chains through trimming chains from the distal end, suggesting a regulatory role in proteostasis (1). It has been reported that MINDY1 is associated with renal function, Chronic Kidney Disease (2), and Alzheimer’s disease (3) through several genome wide studies.
References :
1. Abdul Rehman SA, et al. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Mol Cell, 2016 Jul 7;63(1):146-55.
2. Köttgen A, et al. New loci associated with kidney function and chronic kidney disease. Nat Genet, 2010 May;42(5):376-84.
3. Figgins JA, et al. Association studies of 22 candidate SNPs with late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):520-6.
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Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder