CYLD, Active (C578-380G)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description : Recombinant human CYLD (1-956) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells
Sequence : 1-956
Genbank Number : NM_015247
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 135 kDa
Gene Aliases : EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2
Scientific Background : CYLD is a cytoplasmic deubiquitinating enzyme, which removes ubiquitin molecules from various signaling proteins, and regulates the activities of many cellular and signaling processes. It plays a role in the regulation of inflammation, immunity, cell cycle progression, spermatogenesis, osteoclastogenesis, ciliogenesis, migration and tumorigenesis. (1) Several signaling pathways, such as the Nuclear Factor-kB (NF-kB), Wnt/β-catenin and c-Jun N-terminal kinase (JNK) pathways, and potentially others have been linked with or regulated by CYLD. (2) Mutations in CYLD gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. (3)
References :
1. Bignell G.R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 25(2):160–165, 2000.
2. Verhoeft, K.R. et al The cylindromatosis (CYLD) gene and head and neck tumorigenesis. Cancers Head Neck. 1: 10, 2016.
3. EntreZ Gene: CYLD cylindromatosis (turban tumor syndrome)
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder