BAP1, Active (B504-30H)
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Description : Recombinant full-length human BAP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species : Human
Tag : His tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full Length
Genbank Number : NM_004656
Specific Activity : Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 98 kDa
Gene Aliases : HUCEP-13, KIAA0272, Hucep-6, UCHL2
Scientific Background : BAP1 (BRCA1 associated protein-1) is a deubiquitinating enzyme belonging to the ubiquitin C-terminal hydrolase subfamily and is involved in the ubiquitin removal from proteins. It binds to the RING finger domain of the BCRA1 and acts as a tumor suppressor (1). BAP1 mutations have been found to cause multiple tumour types and high tumour phenotype penetrance, suggesting that it may have a major role in inducing cancer growth (2).
References :
1. Carbone, Michele et al: BAP1 and cancer. Nature reviews. Cancer vol. 13,3: 153-9, 2013.
2. Jensen, D.E. et al: BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene. 16,9: 1097–112, 1998.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder