KDM4A Protein(K424-31G)
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Description :Recombinant human KDM4A (1-886) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1-886
Genbank Number :BC002558
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~150 kDa
Gene Aliases :JMJD2A; JHDM3A; KIAA0677
Scientific Background :KDM4A or lysine (K)-specific demethylase 4A is a member of the Jumonji domain 2 (JMJD2) family that encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. KDM4A functions in euchromatin to remove histone methylation marks that are associated with active transcription (1). KDM4A also act as a trimethylation-specific demethylase those converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor (2).
References :
1. Klose, R. J. et.al: The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442: 312-316, 2006.
2. Whetstine, J. R. et.al: Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125: 467-481, 2006.
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Research Areas :Cancer, Cell Cycle, Inflammation, Cancer, Inflammation, Cell Cycle