NPM1 Protein(N50-30H)
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Description :Full-length recombinant human NPM1 protein was expressed in E.coli cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :Full length
Genbank Number :NM_002520
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~40 kDa
Gene Aliases :Nucleophosmin; B23; MGC104254; NPM
Scientific Background :NPM1 or nucleophosmin (nucleolar phosphoprotein B23, numatrin) is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm which is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia (AML) (1). NPM1 is a target of CDK2/cyclin E in the initiation of centrosome duplication (2). NPM1 is involved in several processes including regulation of the ARF/p53 pathway. NPM1-ALK acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.
References :
1. Garzon, R.et.al: Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc. Nat. Acad. Sci. 105: 3945-3950, 2008.
2. Okuda, M..et.al: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103: 127-140, 2000.
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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Cancer, Apoptosis/Autophagy, Cell Cycle