HtrA Protein(H531-30CH)
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Description :Recombinant streptococcus HtrA (33-393) protein was expressed in bacterial cells using an N-terminal His-tag.
Species :Streptococcus
Tag :His tag
Expression System:E.coli
Sequence :33-393
Genbank Number :B8ZQD0
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~41 kDa
Gene Aliases :SPN23F22720
Scientific Background :HtrA (also designated as DegP) is a trypsin-like serine protease which contains PDZ domain and involves in heat-shock response, chaperone function, and apoptosis (1). HtrA is an error sensor that specifically represses genetic competence when the overall level of biosynthetic errors in cellular proteins is low (2).
References :
1. Ge X. et.al: DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli. FEBS J. 2013 Dec 26. doi: 10.1111/febs.12701.
2. Cassone M. et.al: The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide. J Biol Chem. 2012 Nov 9;287(46):38449-59.
Product Sheets (By Lot #) :
Research Areas :Cell Cycle, Neurobiology, Ser/Thr Kinases, Neurobiology, Cell Cycle, Ser/Thr Kinases