PAD6 Protein (P312-30FG)
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Description : Recombinant full-length human PAD6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : NM_207421
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~100 kDa
Gene Aliases : PADI6
Scientific Background : PAD6 or PADI6 is a member of the peptidylarginine deiminases which convert arginine residues to citrulline residues in the presence of calcium ions. The PAD family members are thought to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis (1). PAD6 is essential for formation of a novel oocyte-restricted fibrous structure, the cytoplasmic lattices (CPLs). PAD6/CPL superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement (2).
References :
1. Vossenaar, E R. Et al: PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays. 2003 Nov;25(11):1106-18.
2. Kan, R. Et al: Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices. Dev Biol. 2011 Feb 15;350(2):311-22.
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Research Areas : Inflammation,