KAT9 (ELP3) Protein(K318-30G)
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Description :Recombinant full-length human KAT9 (ELP3) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_018091
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~86 kDa
Gene Aliases :KAT9; ELP3; FLJ10422
Scientific Background :KAT9 (also known as ELP3) is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons. The knockdown of KAT9 by antisense morpholinos in zebrafish embryos resulted in dose-dependent shortening and abnormal branching of motor neurons with no concomitant morphologic abnormalities (1). KAT9 knockdown also impairs paternal DNA demethylation as indicated by reporter binding, immunostaining, and bisulfite sequencing (2).
References :
1. Simpson, C. L. et.al: Variants of elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum. Molec. Genet. 18: 472-481, 2009.
2. Okada, Y. et.al: A role for the elongator complex in zygotic paternal genome demethylation. Nature 463: 554-558, 2010.
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Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Invasion/Metastasis