KAT8 (MYST1) Protein(K317-31G)
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Description :Recombinant human KAT8 (2-467; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :2-467
Genbank Number :BC037773
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~83 kDa
Gene Aliases :KAT8, MYST1, hMOF, MOF, FLJ14040
Scientific Background :KAT8 (MYST1) or MYST histone acetyltransferase 1 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein which play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. MYST1 have a chromodomain that involved in protein-protein interactions and targeting transcriptional regulators to chromatin (1). MYST histone acetyltransferase 1 is also involved in ATM function (2).
References :
1. Neal, K. C. et.al: A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF. Biochim. Biophys. Acta 1490: 170-174, 2000.
2. Gupta, A. et.al: Involvement of human MOF in ATM function. Molec. Cell. Biol. 25: 5292-5305, 2005.
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Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Invasion/Metastasis