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ZM-447439(A31-901)

ZM-447439(A31-901)

  • $72.00


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Description :Aurora B kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :331771-20-1

Molecular Formula :C29H31N5O4

Appearance :White solid

Melting Point :N/A

Molecular Weight :513.6

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml)

Aliases :(N-[4-[[6-Methoxy-7-[3-(4-morpholinyl) propoxy]-4-quinazolinyl] amino] phenyl] benzamide

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 uM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.

References :
1. C Ditchfield et al J. Cell Biol. 2003 161:267

2. F Girdler et al J. Cell Sci. 2006 119:3664

3. F H Jung et al J. Med. Chem. 2006 49:955

Molecular Structure :

Product Sheets (By Lot #) :

T2257-17.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases