ZM-336372(R01-901)

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Description :c-Raf inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :331771-20-1

Molecular Formula :C23H23N3O3

Appearance :Off white powder

Melting Point :258-260oC

Molecular Weight :513.6

Purity :98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25mg/ml)

Aliases :3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]-benzamide

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20°C for up to 1 month.

Scientific Background :Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50uM) with the exception of p38 (SAPK2a) (IC50=2uM) and SAPK2b (p38beta) (IC50=2uM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Induces apoptosis in a variety of cell lines. Cell permeable.

References :
1. CA Hall-Jackson et al. Chem. Biol. 1999 6:559

2. D Deming et al. J. Surg. Res. 2010 161:28

Molecular Structure :

Product Sheets (By Lot #) :

T2257-10.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Angiogenesis, Ser/Thr Kinases