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ZM-306416(F11-900B)

ZM-306416(F11-900B)

  • $83.00


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Description :VEGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :690206-97-4

Molecular Formula :C16H13ClFN3O2

Appearance :Off-white solid

Melting Point :N/A

Molecular Weight :333.7

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (3 mg/ml); or ethanol (1 mg/ml)

Aliases :4-[(4'-Chloro-2'-fluoro) phenylamino]-6,7-dimethoxyquinazoline

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent inhibitor of VEGF receptor tyrosine kinase, inhibiting KDR (IC50 = 100 nM) and Flt (IC50 = 2 uM). Displays ca 4-fold selectivity over FGFR-1. Orally active (100 mg/kg, rat) (1).

References :
1. LF Hennequin et al J. Med. Chem. 1999 42:5369

Molecular Structure :

Product Sheets (By Lot #) :

T2257-1.pdf

Research Areas :Angiogenesis, Cancer, Cell Cycle, Neurobiology, Cancer, Neurobiology, Cell Cycle, Angiogenesis