YSK4 (MAP3K19), Active(Y06-11G)

YSK4 (MAP3K19), Active(Y06-11G)

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Description :Recombinant human YSK4 (MAP3K19) (941-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :941-end

Genbank Number :NM_025052

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~83 kDa

Gene Aliases :RCK; MAP3K19

Scientific Background :YSK4 (MAP3K19, RCK) belongs to STE Ser/Thr protein kinase family and STE20 subfamily. The YSK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat (1). The important paralog is MAP3K1 gene. The RCK ligand-binding domains form an octameric gating ring (2) in the large-conductance Ca2+-activated K+ channels (3). The YSK4 kinase function has not been made clearly yet.

References :
1. Hillier LW, et al: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature, 2005 Apr 7.

2. Ye S. et al: Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels. Cell (2006).

3. Santarelli, L.C. et al: Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. Physiol. (Lond.) (2006).

Product Sheets (By Lot #) :

Z1359-4.pdf

Q2477-9.pdf

W3089-3.pdf

Research Areas :Cancer, ERK/MAPK Pathway, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, ERK/MAPK Pathway, Ser/Thr Kinases