Y-27632 2HCl(R10-900B)

Y-27632 2HCl(R10-900B)

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Description :ROCK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :129830-38-2

Molecular Formula :C14H21N3O ∙ 2HCl

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :320.3

Purity :99% (HPLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml)

Aliases :(R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl) cyclohexanecarboxamide dihydrochloride

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Specific inhibitor of ROCK family kinases (1). Enhances stem cell survival and proliferation in culture (2). Significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers or differentiation potential (3).

References :
1. T Ishizaki et al. Mol. Pharmacol. 2000 57:976

2. K Gauthaman et al. Stem Cell Rev. 2010 6:86

3. X Li et al. Stem Cells Dev. 2008 17:1079

Molecular Structure :

Product Sheets (By Lot #) :

T2257-75.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Inflammation, Cardiovascular Disease, Apoptosis/Autophagy, Invasion/Metastasis, Ser/Thr Kinases