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Wortmannin(P27-900B)

Wortmannin(P27-900B)

  • $83.00


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Description :PI3K inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :19545-26-7

Molecular Formula :C23H24O8

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :428.4

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (20 mg/ml)

Aliases :None

Storage and Stability :Store desiccated as supplied at -20�C for up to 1 year. Make and use fresh solutions. Do not store stock solutions.

Scientific Background :Potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM). Cell-permeable.

References :
1. Arcaro and Wymann Biochem J. 1993 296:297

2. Powis et al Cancer Res. 1994 54:2419

3. Liu et al Chem .Biol. 2005 12:99

Product Sheets (By Lot #) :

T2257-49.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases