Announcement : SignalChem has changed its corporate name from “SignalChem Pharmaceutical Inc.” to “SignalChem Biotech Inc.” effective March 20th 2019.
WHSC1 (NSD2), Active(N377-381G)

WHSC1 (NSD2), Active(N377-381G)

  • $259.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Recombinant human WHSC1 (911-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :911-end

Genbank Number :NM_133330

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :80 kDa

Gene Aliases :MMSET; WHSC1; REIIBP; TRX5; WHS

Scientific Background :Histone-lysine N-methyltransferase NSD2 or Multiple myeloma SET domain-containing protein (MMSET) is a histone methyltransferase (HMT) with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Overexpressed in t(4;14)+ multiple myeloma (MM) patients, leading to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), accompanied by changes in proliferation, gene expression and chromatin accessibility.

References :
1. Shah MY, et al: MMSET/WHSC1enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.116.

2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816(2):158-63.

Product Sheets (By Lot #) :

L1908-5.pdf

Research Areas :Cancer, NfkB Pathway