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WHI-P131(J03-901)

WHI-P131(J03-901)

  • $204.00


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Description :JAK3 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :202475-60-3

Molecular Formula :C16H15N3O3 ∙ HCl

Appearance :Yellow powder

Melting Point :255-260oC

Molecular Weight :333.8

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml); Ethanol (nil)

Aliases :
1. 4-[(4'-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, Hydrochloride

2. Janex-1

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion (1). Increases survival in a mouse ALS model (2). JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion (1). Increases survival in a mouse ALS model (2).

References :
1. RK Narla et al Clin. Cancer Res. 1998 4:2463

2. VN Trieu et al Biochem. Biophys. Res. Commun. 2000 267:22

Molecular Structure :

Product Sheets (By Lot #) :

T2257-76.pdf

Research Areas :Cancer, Inflammation, Cardiovascular Disease, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases