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Description :Full-length recombinant human WDR5 was expressed in E. coli cells using an N-terminal His tag.
Tag :His tag
Sequence :Full length
Genbank Number :BC001635
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :~40 kDa
Gene Aliases :BIG3; BIG-3
Scientific Background :WD repeat-containing protein 5 (WDR5) is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes. Selectively binds dimethylated Lys4 (K4me2) in histone H3 to promote K4 trimethylation by TRX.
1. Couture JF, et al: Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol. 2006 13(8):698-703.
2. Han Z, et al: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol Cell. 2006 22(1):137-44.
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Research Areas :Cancer, Inflammation, Metabolic Disorder