FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :HDAC Inhibitor
CAS Registry Number :149647-78-9
Molecular Formula :C14H20N2O3
Appearance :White powder
Molecular Weight :264.3
Solubilization :May be dissolved in DMSO (50 mg/ml); or Ethanol (2 mg/ml).
Storage and Stability :Store desiccated as supplied at ambient temperature for up to 5 years. Store solutions at -20oC for up to 1 month.
Scientific Background :Potent and selective histone deacetylase inhibitor1. Induces apoptosis in a variety of tumor cell lines2. Synergizes with kinase inhibitors to kill CNS tumor cells3. Prevents diabetes in a mouse model by immunoregulation and beta-cell protection4. Cell permeable.
1. JA Vrana et al. Oncogene 1999 18:7016
2. LM Butler et al. Proc. Natl. Acad. Sci. USA 2002 99:11700
3. Y Tang et al. Cancer Biol. Ther. 2012 13:567
4. DP Christensen et al. Proc. Natl. Acad. Sci. USA 2014 111:1055
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Inflammation