Vorinostat (SAHA)(H83-904M)

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Description :HDAC Inhibitor

Species :

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Expression System:

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CAS Registry Number :149647-78-9

Molecular Formula :C14H20N2O3

Appearance :White powder

Molecular Weight :264.3

Purity :>98%

Solubilization :May be dissolved in DMSO (50 mg/ml); or Ethanol (2 mg/ml).

Aliases :N-Hydroxy-N’-phenyloctanediamide

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 5 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Potent and selective histone deacetylase inhibitor1. Induces apoptosis in a variety of tumor cell lines2. Synergizes with kinase inhibitors to kill CNS tumor cells3. Prevents diabetes in a mouse model by immunoregulation and beta-cell protection4. Cell permeable.

References :
1. JA Vrana et al. Oncogene 1999 18:7016

2. LM Butler et al. Proc. Natl. Acad. Sci. USA 2002 99:11700

3. Y Tang et al. Cancer Biol. Ther. 2012 13:567

4. DP Christensen et al. Proc. Natl. Acad. Sci. USA 2014 111:1055

Molecular Structure :

Product Sheets (By Lot #) :

P3320-43.pdf

Research Areas :Cancer, Cell Cycle, Inflammation