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Description : Recombinant human VEGF-c was expressed in E. coli cells and purified by proprietary chromatographic techniques.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : tored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Cell Assay
Endotoxin Level : Less than 0.1 ng/ug (IEU/ug) of TRAIL.
Molecular Weight : ~14 kDa
Gene Aliases : VEGFC; VRP; Flt4-L
Scientific Background : VEGF-C is a member of the PDGF/VEGF family which is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. It is structurally and functionally similar to vascular endothelial growth factor D. VEGFC is an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension and tonicity-responsive enhancer-binding protein (TONEBP)-VEGFC signaling in mononuclear phagocytes is a major determinant of extracellular volume and blood pressure homeostasis (1).VEGF-C is also essential for embryonic survival and lymphangiogenesis (2).
1. Machnik, A. et.al: Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nature Med. 15: 545-552, 2009.
2. Karkkainen, M. J. et.al: Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nature Immun. 5: 74-80, 2004.
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Research Areas : Angiogenesis, Cancer, Cell Cycle, Neurobiology,