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Description :Recombinant full-length human VCP was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_007126
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Assay
Molecular Weight :120 kDa
Gene Aliases :ALS14; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; TERA
Scientific Background :VCP (valosin-containing protein or transitional endo-plasmic reticulum ATPase) is a hexameric ATPase. Like many other members of the AAA (ATPases associated with diverse cellular activities) family, it uses the energy of ATP hydrolysis to structurally remodel client molecules. VCP facilitates the degradation of polyubiquitylated substrates in the proteasome. VCP/p97 has also been linked to various membrane trafficking processes, including Golgi reassembly following mitosis.
1. Meyer H, et al: The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci. 2014 Sep 15;127(Pt 18):3877-83.
2. Erzberger JP, et al: Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct. 2006;35:93-114.
3. Meyer HH. Golgi reassembly after mitosis: the AAA family meets the ubiquitin family. Biochim Biophys Acta. 2005 Jun 30;1744(2):108-19. Review. Erratum in: Biochim Biophys Acta. 2005 Dec 15;1746(2):169.
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