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Vatalanib 2HCl(F11-900D)

Vatalanib 2HCl(F11-900D)

  • $72.00


Description :VEGFRK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :212141-51-0

Molecular Formula :C20H15CIN4•2HCl

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :419.7

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (20 mg/ml, warm); or water (100 mg/ml)

Aliases :
1. N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride

2. CGP-79787

3. PTK-787

4. ZK222584

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM) (1). Weaker inhibitor of other tyrosine kinases including PDGFR-beta (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 uM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Calpha (IC50 > 10 uM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.

References :
1. J.M. Wood et al. Cancer Res. 2000 60:2178

2. B. Lin et al. Cancer Res. 2002 62:5019

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Research Areas :Cancer, Neurobiology, Cell Cycle, Angiogenesis