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Valproate NA   (H83-904L)

Valproate NA (H83-904L)

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Description :HDAC Inhibitor

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Expression System:

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CAS Registry Number :1069-66-5

Molecular Formula :C8H15NaO2

Appearance :White powder

Molecular Weight :166.19

Purity :>98% (TLC)

Solubilization :May be dissolved in water (50 mg/ml)

Aliases :Sodium 2-propylpentanoate

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Histone deacetylase inhibitor (IC50=400 uM)1. Demonstrates neuroprotective, anticancer and anti-inflammatory activity2. Inhibits Abeta production, reduced neuritic plaque formation and improved memory deficits in Alzheimer’s mouse models3. Improves stem cell reprogramming efficiency and enables efficient induction of pluripotency without introduction of the oncogene c-Myc4. Clinically useful anticonvulsant.

References :
1. CJ Phiel et al. J. Biol. Chem. 2001 276:36734

2. HJ Kim et al. J. Pharmacol. Exp. Ther. 2007 321:892

3. H Qing et al. J. Exp. Med. 2008 205:2781

4. D Huangfu et al. Nature Biotechnol. 2008 26:795

Molecular Structure :

Product Sheets (By Lot #) :

P3320-42.pdf

Research Areas :Cancer, Cell Cycle, Inflammation