FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Methyltransferase Inhibitor
CAS Registry Number :1431612-23-5
Molecular Formula :C33H43N7O2
Appearance :White powder
Molecular Weight :569.74
Purity :>98% (HPLC)
Solubilization :May be dissolved in DMSO (10 mg/ml)
Storage and Stability :Store desiccated at -20oC. Store solutions at -20oC for 3 months.
Scientific Background :UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 = 45 nM and 2 nM respectively)1. Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells2. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells3.
1. KD Konze et al. ACS Chem. Biol. 2013 8:1324
2. BW Katona et al. Cancer Biol. Ther. 2014 15:1677
3. B Xu et al. Blood 2015 125:346
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology