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UNC1999(D353-904E)

UNC1999(D353-904E)

  • $127.00


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Description :Methyltransferase Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1431612-23-5

Molecular Formula :C33H43N7O2

Appearance :White powder

Molecular Weight :569.74

Purity :>98% (HPLC)

Solubilization :May be dissolved in DMSO (10 mg/ml)

Aliases :N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide

Storage and Stability :Store desiccated at -20oC. Store solutions at -20oC for 3 months.

Scientific Background :UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 = 45 nM and 2 nM respectively)1. Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells2. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells3.

References :
1. KD Konze et al. ACS Chem. Biol. 2013 8:1324

2. BW Katona et al. Cancer Biol. Ther. 2014 15:1677

3. B Xu et al. Blood 2015 125:346

Molecular Structure :

Product Sheets (By Lot #) :

P3320-41.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology