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UBE2N (UBC13), Active(U231-380H)

UBE2N (UBC13), Active(U231-380H)

  • $215.00


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Description :Recombinant human UBE2N (2-end) was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :His tag

Expression System:E.coli

Sequence :2-end

Genbank Number :NM_003348

Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Ubiquitin Enzyme Assay, Western Blot

Molecular Weight :18 kDa

Gene Aliases :UBC13; UbcH-ben

Scientific Background :UBE2N (UBC13) or ubiquitin-conjugating enzyme E2N is a member of the E2 ubiquitin-conjugating enzyme family which plays a role in DNA post-replication repair. UBE2N gene encodes a novel human E2 that may be involved in protein degradation in the muscles and testis. UBE2N plays a role in initiation of homologous recombination during double-strand break repair. UBE2N activity may have therapeutic uses in controlling inflammatory responses and it is also important in the induction of immune responses.

References :
1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016

2. Yamaguchi, T. et al: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. J. Biochem. 120: 494-497, 1996

3. Zhao, G.Y. et al: A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Molec. Cell 25: 663-675, 2007

Product Sheets (By Lot #) :

V2408-15.pdf

Research Areas :Cancer, Cell Cycle, Neurobiology