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UBE2K (UBC1), Active(U227-380H)

UBE2K (UBC1), Active(U227-380H)

  • $215.00


Description :Recombinant full-length human UBE2K was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :His tag

Expression System:E.coli

Sequence :Full length

Genbank Number :NM_005339

Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Ubiquitin Enzyme Assay, Western Blot

Molecular Weight :26 kDa

Gene Aliases :E2-25K; HIP2; HYPG; LIG; UBC1

Scientific Background :UBE2K also known as UBC1 or ubiquitin-conjugating enzyme E2K belongs to the ubiquitin-conjugating enzyme family which interacts with RING finger proteins. UBE2K can ubiquitinate huntingtin, the gene product for Huntington's disease. Huntingtin is ubiquitinated in peripheral cells, suggesting a role for UBE2K in the degradation of huntingtin. UBE2K plays a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases. UBE2K also plays a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation.

References :
1. Kalchman, M.A. et al: Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J. Biol. Chem. 271: 19385-19394, 1996

2. De Pril, R. et al: Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. Mol Cell Neurosci. 2007 Jan;34(1):10-9

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Research Areas :Cancer, Cell Cycle, Neurobiology