UBE2G1 (UBC7), Active(U221-380H)
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Description :Recombinant full-length human UBE2G1 was expressed in E. coli cells using an N-terminal His tag.
Tag :His tag
Sequence :Full length
Genbank Number :NM_003342
Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Ubiquitin Enzyme Assay, Western Blot
Molecular Weight :21 kDa
Gene Aliases :UBC7; E217K; UBE2G
Scientific Background :UBE2G1 (UBC7) or ubiquitin-conjugating enzyme E2G 1 is a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins which are involved in degradation of muscle-specific proteins. UBC7 is highly expressed in skeletal muscle. UBC7 is involved in the selective ubiquitylation of different substrates by the same E3 complex.
1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016
2. Watanabe, T.K. et al: Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. Cytogenet. Cell Genet. 74: 146-148, 1996
3. David, Y. et al: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. Cytogenet. J Biol Chem. 285(12): 8595-8604, 2010
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Research Areas :Cancer, Cell Cycle, Neurobiology