UBE2E1 (UBCH6), Active(U217-380H)
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Description :Recombinant human UBE2E1 (2-end) was expressed in E. coli cells using an N-terminal His tag.
Tag :His tag
Genbank Number :NM_003341
Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Ubiquitin Enzyme Assay, Western Blot
Molecular Weight :~27 kDa
Gene Aliases :UBCH6
Scientific Background :Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) belongs to the ubiquitin-conjugating enzyme family. It accepts ubiquitin activated by the E1 complex and catalyzes its covalent attachment to short-lived and abnormal proteins, and mediates their selective degradation. It was also found to be responsible for 'Lys-48'-linked polyubiquitination in vitro.
1. David Y, et al. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem. 2010 19; 285:8595-604.
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Research Areas :Cancer, Cell Cycle, Neurobiology