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UBA7(UBE1L), Active(U207-380G)

UBA7(UBE1L), Active(U207-380G)

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Description :Recombinant full-length human UBA7 (UBE1L) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_003335

Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Ubiquitin Enzyme Assay, Western Blot

Molecular Weight :~138 kDa

Gene Aliases :D8; UBE2; UBA1B; UBA7; UBE1L

Scientific Background :UBA7 or ubiquitin-like modifier activating enzyme 7 is a member of the E1 ubiquitin-activating enzyme family which is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBA7 is expressed in a variety of tissues, including normal lung, but highly expressed in a large series of lung cancer cell lines (1). UBA7 may represent a second, autosomal member of the ubiquitin-activating gene family, which play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes (2).

References :
1. Carritt, B. et.al: A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. Cancer Res. 52: 1536-1541, 1992.

2. Kok, K. et.al: A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. Proc. Nat. Acad. Sci. 90: 6071-6075, 1993.

Product Sheets (By Lot #) :

L2220-10.pdf

Research Areas :Cancer, Cell Cycle, Neurobiology