UCHL5, Active (U526-380H)

UCHL5, Active (U526-380H)

  • $226.00


Description :  Recombinant full length human UCHL5, was expressed in E. coli cells using an N-terminal His tag.

Species : Human

Tag : His tag

Expression System : E.coli

Sequence : Full length

Genbank Number : NM_001199261

Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Activity Assay, Western Blot

Molecular Weight :  38 kDa

Gene Aliases :  UCH-L5, UCH37, CGI-70, INO80R

Scientific Background : UCHL5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) is a member of the peptidase C12 family of deubiquitinating enzymes and specially cleaves 'Lys-48'-linked polyubiquitin chains. UCHL5 is associated with the 19S regulatory subunit of the 26S proteasome and may play a role as a putative regulatory component of the INO80 complex (1). High expression of UCHL5 has also been indicated to be correlated with increased disease-specific survival in lymph-node-positive rectal cancer, suggesting that it could be a possible novel prognostic marker (2).

References : 
1. Yao, T.T. et al: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Molecular cell 31(6): 909-17, 2008.

2. Arpalahti, L. et al: UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. Tumor Biology: 1-8, 2017.

Product Sheets: (by Lot #):


Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder