UBE2Z (USE1) Protein(U241-31H)

UBE2Z (USE1) Protein(U241-31H)

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Description :Recombinant human UBE2Z (USE1) (109-end) was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :HIS tag

Expression System:E.coli

Sequence :109-end

Genbank Number :NM_023079

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~30 kDa

Gene Aliases :HOYS7; USE1

Scientific Background :UBE2Z(USE1) encodes the ubiquitin conjugating enzyme (E2) which is involved in Ubiquitination, the covalent attachment of the protein ubiquitin (Ub) to other cellular proteins (1). UBE2Z plays an important role in the ubiquitin process and has been implicated in a number of important physiological processes including apoptosis. UBE2Z is specifically charged with ubiquitin by UBA6 (2). UBE2Z is widely expressed in human tissues and expression is especially high in placenta, pancreas, spleen and testis.

References :
1. Gu, X. et al: Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z). Mol Biol Rep. 2007 Sep;34(3):183-8.

2. Jin, J. et.al: Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature 447: 1135-1138, 2007.

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Research Areas :Neurobiology, Cell Cycle, Cancer