TXK, Active (T19-11CG)

TXK, Active (T19-11CG)

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Description :Recombinant rat TXK (190-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.

Species :Rat

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :190-end

Genbank Number :BC095847

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~64 kDa

Gene Aliases :RLK; TKL; BTKL; PTK4; PSCTK5

Scientific Background :TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity (1). Excessive TXK protein expression is seen in patients with Behcet's disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet’s disease (2).

References :
1. Czar, M J. et al: Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk. Biochem Soc Trans. 2001 Nov;29(Pt 6):863-7.

2. Suzuki, N. et al: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Clin Med Res. 2006 Jun;4(2):147-51.

Product Sheets (By Lot #) :

K1661-3.pdf

 Research Areas :Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, Cancer, Inflammation, Cytoplasmic Tyrosine Kinases