Tubastatin A · HCL(H83-904K)

Tubastatin A · HCL(H83-904K)

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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1239262-52-2

Molecular Formula :C20H21N3O2·HCl

Appearance :white powder

Molecular Weight :371.9

Purity :99% (HPLC)

Solubilization :May be dissolved in DMSO (50 mg/ml)

Aliases :N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride

Storage and Stability :Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8)1. Inhibits TNFalpha (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models2. Improves survival in animal models of sepsis3. Improves cognition in Alzheimer's disease transgenic mice4. Cell permeable.

References :
1. KV Butler et al. J. Am. Chem. Soc. 2010 132:10842

2. S Vishwakarma et al. Int. Immunopharmacol. 2013 16:72

3. T Zhao et al. J. Surg. Res. 2014 190:647

4. L Zhang et al. J. Alzheimers Dis. 2014 41:1193

Molecular Structure :

Product Sheets (By Lot #) :

P3320-40.pdf

Research Areas :Cancer, Cell Cycle, Inflammation