TSSK2, Active(S38-10G)

TSSK2, Active(S38-10G)

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Description :Recombinant full-length human TSSK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_053006

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~66 kDa

Gene Aliases :DGS-G, SPOGA2, STK22B, FLJ38613

Scientific Background :TSSK2 is an intronless serine-threonine kinase that was originally detected on mouse chromosome 16 (1). TSSK2 and TSSK1 share 72% overall amino acid identity and 83% identity in the kinase domain (2). Real-time PCR showed abundant TSSK2 expression in testis and lower levels in heart, brain, and placenta while Western blot analysis detected TSSK2 at the predicted molecular mass of 40kDa in human sperm and testis. Co-immunoprecipitation and yeast 2-hybrid analysis show that TSSK2 can interact with a protein TSKS, that also acts as a substrate for this protein kinase.

References :
1. Nayak, S. et al: Immunohistochemical analysis of the expression of two serine-threonine kinases in the maturing mouse testis. Mech Dev. 1998 Jun;74(1-2):171-4.

2. Hao, Z. et al: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues: a TSSK member is present in the equatorial segment of human sperm. Molec. Hum. Reprod. 10: 433-444, 2004.

Product Sheets (By Lot #) :

Q089-1.pdf

E3139-12.pdf

S180-3.pdf

Research Areas :Cancer, Cardiovascular Disease, Ser/Thr Kinases, Cancer, Cardiovascular Disease, Ser/Thr Kinases