TSLP(T896-40N)

TSLP(T896-40N)

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Description :Recombinant Human TSLP was expressed in E. coli cells.

Species :Human

Tag :

Expression System:E.coli

Sequence :

Genbank Number :Q969D9

Storage, Stability and Shipping :The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :<1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight :15.0 kDa

Gene Aliases :Thymic stromal lymphopoietin, TSLP
Recombinant Human Thymic Stromal Lymphopoietin (TSLP)

Reconstitution Protocol :A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Scientific Background :TSLP is a hemopoietic protein that was initially identified from mouse thymic stromal cell line that promoted the development of B cells. TSLP overlaps biological activities with IL-7 and can co-stimulate growth of thymocytes and mature T cells alongside supporting lymphopoiesis. Human TSLP shares approximately 43% amino acid sequence identity with mouse TSLP. Human TSLP has been detected in many tissues although the highest level of expression has been found in the heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7R-alpha and the TSLP-R.

Sample Cell Assay Data :The ED(50) was determined by the dose-dependent proliferation of human IL-7R-alpha and human TSLP R co-transfected mouse BaF3 cells, was found to be < 3.0 ng/mL.

Purity :Recombinant Human TSLP resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250

Product Sheets (By Lot #) :

G3223-21.pdf

Research Areas :Cancer