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Trichostatin A(H83-904J)

Trichostatin A(H83-904J)

  • $182.00


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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :58880-19-6

Molecular Formula :C17H22N2O3

Appearance :Tan powder

Melting Point :150-151oC

Molecular Weight :302.4

Purity :>99%

Solubilization :May be dissolved in DMSO (15 mg/ml); or ethanol (3 mg/ml)

Aliases :(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Storage and Stability :Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent and selective histone deacetylase (HDAC) inhibitor (Ki=3.4 nM)1. Induces reversion of ras-transformed cells to normal morphology2. Induces dedifferentiation of primordial germ cells into embryonic germ cells3. Cell permeable. Active in vivo.

References :
1. M Yoshida et al. J. Biol. Chem. 1990 265:17174

2. M Futamura et al. Oncogene 1995 10:1119

3. G Durcova-Hills et al. PLoS-One 2008 3:e3531

Molecular Structure :

Product Sheets (By Lot #) :

P3320-39.pdf

Research Areas :Cell Cycle, Cancer, Inflammation