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  • $83.00


Description :Demethylase Inhibitor

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Expression System:

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CAS Registry Number :13492-01-8

Molecular Formula :C9H11N · 1/2H2SO4

Appearance :White powder

Molecular Weight :182.2

Purity :>98% (TLC)

Solubilization :May be dissolved in water (25 mg/ml)

Aliases :Trans (±)-2-phenylcyclopropanamine; 2-PCPA

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50 < 2 uM1,2. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox23. Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells4. Upregulates CD86 expression in THP1 cells5. Cell permeable and active in vivo.

References :
1. NG Lee et al. Chem. Biol. 2006 13:563

2. DM Schmidt and DG McCafferty Biochemistry 2007 46:4408

3. W Li et al. Stem Cells 2009 27:2992

4. D Ding et al. Fertil. Steril. 2014 101:740

5. JT Lynch et al. Anal. Biochem. 2013 442:104

Molecular Structure :

Product Sheets (By Lot #) :


Research Areas :Cancer, Cell Cycle, Inflammation