TRAF1 Protein (T56-30G)
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Description : Recombinant full-length human TRAF1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : NM_005658
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~74 kDa
Gene Aliases : EBI6, MGC:10353
Scientific Background : Tumor necrosis factor receptor-associated factor 1 (TRAF1) is a member of the TNF receptor-associated factor (TRAF) family. Unlike other members of the TRAF family, it lacks the N-terminal RING/zinc-finger domain. As an adapter protein, TRAF1 regulates the activation of NF-kappa-B and JNK and plays a role in the regulation of cell survival and apoptosis. TRAF1 has been shown as a substrate of PKN1 kinase activity (1). TRAF1 inhibits TNFR2-induced proteasomal degradation of TRAF2 and relieves TNFR1-induced activation of NFκB from the inhibitory effect of TNFR2 (2)
1. Kato T. Jr. et al: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. Genes Cells 13:509-520(2008)
2. Wicovsky A. et al: Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene 28:1769-1781(2009)
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Research Areas : AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling,