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TPX2 Protein(T40-30H)

TPX2 Protein(T40-30H)

  • $160.00


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Description :Recombinant full-length human TPX2 protein was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. This product can be used for Aurora A activation in vitro.

Species :Human

Tag :HIS tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_012112

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase assay, Western Blot

Molecular Weight :~110 kDa

Gene Aliases :DIL2, p100, DIL-2, HCTP4, FLS353, HCA519, REPP86, C20orf1, C20orf2, GD:C20orf1

Scientific Background :TPX2 is a nuclear proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M (1). It mainly expressed in the lung carcinoma cell lines and also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney.TPX2 is required for targeting STK6 to the spindle apparatus, and that STK6 may regulate the function of TPX2 during spindle assembly. TPX2 is mailnly function in mitotic spindle assembly likely contributes to its role in chromosome stability control and tumor suppression (2).

References :
1. Heidebrecht, H. J. et.al: p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. Blood 90: 226-233, 1997.

2. Joukov, V.et.al: The BRCA1/BARD1 heterodimer modulates Ran-dependent mitotic spindle assembly. Cell 127: 539-552, 2006.

Product Sheets (By Lot #) :

N224-2.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Invasion/Metastasis, Neurobiology, Cancer, Neurobiology, Apoptosis/Autophagy, Cell Cycle, Invasion/Metastasis