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TPM3-PDGFR beta, Active(P13-19DG)

TPM3-PDGFR beta, Active(P13-19DG)

  • $435.00


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Description :Recombinant human TPM3-PDGFRB, the fusion protein [TPM3 (1-258)-PDGFRB (528-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-258 (TPM3) - 528-end (PDGFRB)

Genbank Number :NM_152263

Genbank Number 2 :NM_002609

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~150 kDa

Gene Aliases :TPM3: CAPM1; CFTD; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3
PDGFRB: JTK12, PDGFR, CD140B, PDGFR1, PDGF-R-beta

Scientific Background :TPM3 is an actin-binding protein that mediates myosin–actin response to calcium ions in skeletal muscles. PDGFRB is a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. PDGFRB is located at chromosome 5q31-33, and has been reported to have at least 18 fusion partners. It was uncovered that the TPM3 gene at 1q21 as a PDGFRB partner in chronic eosinophilic leukemia (CEL).

References :
1. Rosati R, et al. TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukemia. Leukemia. 20(9):1623-4, 2006.

2. Li Z, Yang R, Zhao J, Yuan R, Lu Q, Li Q, Tse W. Molecular diagnosis andtargeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion. Pediatr Blood Cancer. 56(3):463-6. 2011.

Product Sheets (By Lot #) :

K1730-1.pdf

Research Areas :Cancer