TNK1, Active(T12-11G)

TNK1, Active(T12-11G)

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Description :Recombinant human TNK1 (1-510) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-510

Genbank Number :NM_003985

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~85 kDa

Gene Aliases :MGC46193

Scientific Background :TNK1 or tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family which are important regulators of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene (1).

References :
1. Hoehn, G. T. et.al: Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34(+)/Lin(-)/CD38(+) stem/progenitor cells. Oncogene 12: 903-913, 1996.

Product Sheets (By Lot #) :

P1748-5.pdf

M2672-6.pdf

W3254-6.pdf

Research Areas :Cancer, Inflammation, JAK/STAT Pathway, Neurobiology, NfkB Pathway